منابع مشابه
Caspases and cancer: mechanisms of inactivation and new treatment modalities.
Elimination of superfluous or mutated somatic cells is provided by various mechanisms including apoptosis. Deregulation of apoptotic signaling pathways may contribute to oncogenesis. Aspartate specific cysteine proteases, termed caspases are the key effector molecules in apoptosis. The aim of this review is to summarize the various defects in caspase-dependent cell death machinery identified in...
متن کاملCaspases
U ncontrolled lymphoproliferation is a characteristic feature of lymphomas and leukemias. Nonmalignant lym-phoproliferative diseases are also observed in humans as well as in lpr (lymphoproliferation) and gld (generalized lymphad-enopathy) mice. The discoveries that spontaneous mutations of Fas (APO-1/CD95) or its ligand (FasL) were associated with the lpr and gld phenotypes led to a satisfying...
متن کاملDeath without caspases, caspases without death.
Apoptosis is a conserved cell-death process displaying characteristic morphological and molecular changes including activation of caspase proteases. Recent work challenges the accepted roles of these proteases. New investigations in mice and the nematode Caenorhabditis elegans suggest that there could be caspase-independent pathways leading to cell death. In addition, another type of cell death...
متن کاملEffector Caspases and Leukemia
Caspases, a family of aspartate-specific cysteine proteases, play a major role in apoptosis and a variety of physiological and pathological processes. Fourteen mammalian caspases have been identified and can be divided into two groups: inflammatory caspases and apoptotic caspases. Based on the structure and function, the apoptotic caspases are further grouped into initiator/apical caspases (cas...
متن کاملSnapShot: Caspases
(Cell 146, 633–644; August 19, 2011) In theDiscussionof theabovearticle,weneglected tociteChaffer et al. (2011),who recently identifiedplasticity in cancercell populations inwhich non-stemcancer cells cangive rise to cancer stem-like cells. Their findings, togetherwithour analysesof breast cancer cell lines and their ability to regenerate equilibrium populations of stem and non-stem cells, esta...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2011
ISSN: 1350-9047,1476-5403
DOI: 10.1038/cdd.2011.30